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Insights

Ideas from the edge of drug delivery.

Short reads on the delivery problem behind modern medicine, our approach to proving it in people, and the science that makes the platform work.

The problem

Why the most promising medicines are the hardest to deliver

Proteins, peptides and RNA are more precise and potent than the drugs before them, and our delivery tools handle them worst. Here is why that gap exists, and how our delivery system solves it.

Read → Our approach

Human proof of concept

Most delivery technologies rest on a translational leap from preclinical models. We start in people. Why that choice changes the risk on the whole platform.

Read → The science

What cells already know: learning delivery from nanotubes

Biology solved cell-to-cell transport long ago. More than 50 human cell types build fine membrane tubes to share material. What that teaches us about delivery.

Read →
Research

Collaborative publications.

Publications

  • Large-Scale Fluorescence Microscopy Analysis of Lipid Membrane Conformational Changes, Optimized and Enabled by an AI-Guided Image Detection Method.

    Akira Yamamoto, Tapash Jay Sarkar et al. J. Exp. Theor. Anal. 4(1):3, Jan 5, 2026. DOI 10.3390/jeta4010003

    A method for analysing very large fluorescence microscopy datasets of lipid membranes, using AI-guided image detection to find conformational changes at a scale manual review cannot reach. Funded in part by reThink64.

Co-authored by reThink64 scientists

  • Blue Fluorescent Siloxytecans Exhibit Potent Anticancer Activity and Real-Time Intracellular Uptake.

    Includes Akira Yamamoto and Joseph Pazzi. ACS Bio & Med Chem Au 6(1):1, Dec 20, 2025. DOI 10.1021/acsbiomedchemau.5c00155

    Fluorescent camptothecin derivatives whose entry into cells can be followed in real time. Two reThink64 scientists are co-authors.

Publications by our team

  • Carmofur analogs as antiproliferative agents and SARS-CoV-2 Mpro inhibitors.

    Includes Joseph Pazzi. Discover Chemistry, Apr 7, 2025. DOI 10.1007/s44371-025-00144-9

    Small-molecule antiproliferative work. Our Director of Formulation is a co-author.

Jay Sarkar publishes as Tapash Jay Sarkar.

Talks and events

Where we present the work.

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Want to go deeper?

If delivery or stability are your problems, or your thesis, we should talk.

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